Arkadia rabbit pAb

简要描述：SourceRabbitApplicationsWB,ELISAReactivityHuman,MouseDilutionWB:1:500-1:2000

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详细介绍

Source

Rabbit
Applications

WB,ELISA
Reactivity

Human,Mouse
Dilution

WB: 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950
Uniprot No

Q6ZNA4
Alternative names

RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

ring finger protein 111(RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],
Other

RNF111, E3 ubiquitin-protein ligase Arkadia
Mol.Wt (Da)

108876
Concentration

1 mg/ml

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