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ALK (phospho Tyr1507) rabbit pAb

简要描述:SourceRabbitApplicationsWB,IHC,ELISAReactivityHuman,Mouse,MonkeyDilutionWB:1:500-1:2000

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  • 更新时间:2024-05-16
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详细介绍

  • Source

    Rabbit

  • Applications

    WB,IHC,ELISA

  • Reactivity

    Human,Mouse,Monkey

  • Dilution

    WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. ELISA: 1:5000. Not yet tested in other applications.

  • Storage

    -20°C/1 year

  • Specificity

    Phospho-ALK (Y1507) Polyclonal Antibody detects endogenous levels of ALK protein only when phosphorylated at Y1507.

  • Source/Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen

    The antiserum was produced against synthesized peptide derived from human ALK around the phosphorylation site of Tyr1507. AA range:1473-1522

  • Uniprot No

    Q9UM73

  • Alternative names

    ALK; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD antigen CD246

  • Form

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Background

    anaplastic lymphoma receptor tyrosine kinase(ALK) Homo sapiens This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome

  • Other

    ALK, ALK tyrosine kinase receptor

  • Mol.Wt (Da)

    176428

  • Concentration

    1 mg/ml

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