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Catenin-β (phospho Tyr654) rabbit pAb

简要描述:SourceRabbitApplicationsWB,IHC,ELISAReactivityHuman,Mouse,RatDilutionWB:1:500-1:2000

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  • 更新时间:2024-11-27
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详细介绍

  • Source

    Rabbit

  • Applications

    WB,IHC,ELISA

  • Reactivity

    Human,Mouse,Rat

  • Dilution

    WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. ELISA: 1:40000. Not yet tested in other applications.

  • Storage

    -20°C/1 year

  • Specificity

    Phospho-Catenin-β (Y654) Polyclonal Antibody detects endogenous levels of Catenin-β protein only when phosphorylated at Y654.

  • Source/Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen

    The antiserum was produced against synthesized peptide derived from human Catenin-beta around the phosphorylation site of Tyr654. AA range:620-669

  • Uniprot No

    P35222

  • Alternative names

    CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin

  • Form

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Background

    catenin beta 1(CTNNB1) Homo sapiens The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016],

  • Other

    CTNNB1, Catenin beta-1

  • Mol.Wt (Da)

    85497

  • Concentration

    1 mg/ml

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